Revisiting aromatic diazotization and aryl diazonium salts in continuous flow: highlighted research during 2001–2021

文献情報

出版日 2022-02-28

DOI 10.1039/D2RE00001F

インパクトファクター 4.239

著者

Jianli Chen, Xiaoxuan Xie, Jiming Liu, Zhiqun Yu, Weike Su

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要旨

Aryl diazonium salts play an important role in chemical transformations; however their explosive nature limits their applications in batch. Continuous flow technology allows safer operation for diazotization and application of aryl diazonium salts. Moreover, the other characteristics of continuous flow, such as laminar flow, residence time control, flow reactors with a larger surface area-to-volume ratio, the flexibility of equipment, etc., have significantly improved the reaction efficiency and industrialization potential of diazotization and aryl diazonium salts in various types of chemical transformations. However, the transformation from batch to continuous flow is still accompanied by new challenges (e.g., solid management, automation, and process analytical technology). Therefore, the application of aryl diazonium salts in continuous flow systems is closely related to the upgrade of continuous flow technology. In this article, an overview of aromatic diazotization and applications of aryl diazonium salts in continuous flow systems was described in detail.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.