Two-stage thiol-based click reactions for the preparation and adhesion of hydrogels

文献情報

出版日 2020-04-06

DOI 10.1039/C9PY01503E

インパクトファクター 5.582

著者

Wen Jing Yang, Wenya Xu, Xi Tao, Wen Wang, Yaqin Hu, Xue Li, En-Tang Kang, Lianhui Wang

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要旨

The fabrication of adhesive hydrogel systems is quite important for biological applications. Herein, two-stage thiol-based click reactions have been employed for the preparation and adhesion of hydrogels. In the first stage, two self-adhesive hydrogels (HG-1 and HG-2) were constructed via the thiol-based click reactions and thiol–thiol coupling reaction under different stimuli, employing the same functional copolymer poly(propargyl methacrylate-co-N-(3,4-dihydroxyphenethyl) methacrylamide-co-poly(ethylene glycol) methyl ether methacrylate) (poly(PMA-co-DMA-co-PEGMA), polyPDP) and a 4-arm thiol-PEG cross-linker. Subsequently, the two prepared hydrogels achieved responsive self-adhesion properties via the second stage of thiol-based click reactions between the preserved functional groups under different stimuli. Moreover, the self-adhered hydrogels exhibited increased mechanical strength after adhesion. The present strategy thus provides a facile approach for the fabrication of hydrogel systems with on-demand self-adhesive properties.

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掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Two-stage thiol-based click reactions for the preparation and adhesion of hydrogels

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Front cover

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Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets

Introducing the metacore concept for multi-target ligand design

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

Structural modifications that increase gut restriction of bile acid derivatives

SAR study of 4-arylazo-3,5-diamino-1H-pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

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