Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

文献情報

出版日 2021-05-13

DOI 10.1039/D1MD00058F

インパクトファクター 0

著者

Riccardo Ronchetti, Andrea Carotti, Antimo Gioiello, Emidio Camaioni

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要旨

Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein, we provide an overview of the state-of-the-art of urea and thiourea-containing pharmaceuticals. We also review the diverse approaches pursued for (thio)urea bioisosteric replacements in medicinal chemistry applications. Finally, representative examples of recent advances in the synthesis of urea- and thiourea-based compounds by enabling chemical tools are discussed.

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掲載誌

RSC Medicinal Chemistry

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年間論文数: 0

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

文献情報

おすすめジャーナル

関連文献

Development of portable defocusing micro-scale spatially offset Raman spectroscopy

A magnetic nanoparticle-based aptasensor for selective and sensitive determination of lysozyme with strongly scattering silver nanoparticles

Enzyme-linked immunosorbent assay utilizing thin-layered microfluidics

Quantitative analysis of trace palladium contamination in solution using electrochemical X-ray fluorescence (EC-XRF)

Strong electrochemiluminescent interactions between carbon nitride nanosheet–reduced graphene oxide nanohybrids and folic acid, and ultrasensitive sensing for folic acid

A flowing atmospheric pressure afterglow as an ion source coupled to a differential mobility analyzer for volatile organic compound detection

A rhodol-hemicyanine based ratiometric fluorescent probe for real-time monitoring of glutathione dynamics in living cells

Functionalization of metal nanoclusters for biomedical applications

Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis

Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure

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RSC Medicinal Chemistry

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