A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡

文献情報

出版日 2013-04-08

DOI 10.1039/C3PY00347G

インパクトファクター 5.582

著者

Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent

原文を見る

要旨

A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of α-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.

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掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A controlled and versatile NCA polymerization method for the synthesis of polypeptides‡

文献情報

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関連文献

Hindrance-functionalized π-stacked polymer based on polystyrene with pendent cardo groups for organic electronics

Biodegradable polyphosphazenes containing antibiotics: synthesis, characterization, and hydrolytic release behavior

A facile method to produce PBS-PEG/CNTs nanocomposites with controllable electro-induced shape memory effect

Controlled thiol–ene post-polymerization reactions on polyferrocenylsilane homopolymers and block copolymers

Light induced molecular release from vesicles based on amphiphilic linear-dendritic block copolymers

Nucleophilic thiol-Michael chemistry and hyperbranched (co)polymers: synthesis and ring-opening metathesis (co)polymerization of novel difunctional exo-7-oxanorbornenes with in situ inimer formation

Vinyl-monomer with lysine side chains for preparing copolymer surfaces with fibrinolytic activity

Intracellular pH-sensitive supramolecular amphiphiles based on host–guest recognition between benzimidazole and β-cyclodextrin as potential drug delivery vehicles

A self-healing supramolecular polymer gel with stimuli-responsiveness constructed by crown ether based molecular recognition

Living radical polymerization of vinyl acetate and methyl acrylate mediated by Co(Salen*) complexes

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掲載誌

Polymer Chemistry

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