Asymmetric synthesis of (E)-Secobutanolides: total synthesis and structural revision of (+)-Litseakolide F and G

文献情報

出版日 2023-10-25

DOI 10.1039/D3QO01523H

インパクトファクター 5.281

著者

Dong Guk Nam, Jin Won Lee, Hyun Sil Jung, Do Hyun Ryu

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要旨

Optically active (E)-β-branched Morita–Baylis–Hillman (MBH) esters were prepared through a catalytic Michael-aldol MBH reaction and Z → E isomerization, which were successfully carried out using both photochemical and thermal methods. In this study, we report the first asymmetric synthesis of the (E)-Secobutanolide series and (+)-Litseakolide F and G, using an optically enriched iodo MBH ester. These investigations led us to propose revised structures for the natural products (+)-Litseakolide F and G.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Asymmetric synthesis of (E)-Secobutanolides: total synthesis and structural revision of (+)-Litseakolide F and G

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