Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

文献情報

出版日 2023-02-21

DOI 10.1039/D3AN00084B

インパクトファクター 4.616

著者

Shuai Lv, Xinxin Xu, Lingling Guo, Liguang Xu, Liqiang Liu, Chuanlai Xu

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要旨

Cannabidiol (CBD), the most predominant cannabinoid, may cause addiction and liver damage. In this study, we synthesized a CBD hapten containing the carboxyl group of the spacer arm by derivatizing CBD. A highly specific and sensitive monoclonal antibody (mAb) was prepared with a half-maximal inhibitory concentration of 2.03 ng mL−1 and a limit of detection of 0.32 ng mL−1. MAb was highly specific for CBD. We developed an immunochromatographic assay (ICA) for the detection of CBD in functional beverages with a visible limit of detection of 100 ng mL−1 and a cut-off of 1000 ng mL−1. Compared with HPLC, ICA is more efficient and accurate and can be used for the rapid on-site detection of CBD in samples.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

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