Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates

文献情報

出版日 2021-12-01

DOI 10.1039/D1QO01654G

インパクトファクター 5.281

著者

Xinxin Han, Xin Liu, Yueyun Bao, Hunahuan Song, Yu-Rou Zhao, Xiaoying Wang, Junjie Zhang, Le Liu, Xin-Hua Duan, Jinbo Hu, Mingyou Hu

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要旨

An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted. Pre-generated CuCF3 was used as a trifluoromethylation reagent and water acted as both a promoter and proton source. The reaction is compatible with a broad scope of functional groups and easy to scale-up. The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Water-promoted regio-selective trifluoromethylation of vinyl conjugated diazoacetates

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