Rh-Catalyzed nitrene alkyne metathesis/formal C–N bond insertion cascade: synthesis of 3-iminoindolines

文献情報

出版日 2020-04-08

DOI 10.1039/D0QO00294A

インパクトファクター 5.281

著者

Kemiao Hong, Su Zhou, Wenhao Hu

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要旨

A Rh2(esp)2 catalyzed nitrene/alkyne metathesis (NAM) cascade reaction of alkyne-tethered sulfamates has been developed, which provides facile access to the tricyclic 3-iminoindolines in good to excellent yields with broad substrate scope. The reaction is initiated by a Rh-promoted nitrene/alkyne metathesis (NAM) under oxidative conditions to form the key α-imino metal carbene intermediate, followed by a formal carbene insertion reaction of the amide C–N bond via a Stevens [1,2]-acyl shift.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Rh-Catalyzed nitrene alkyne metathesis/formal C–N bond insertion cascade: synthesis of 3-iminoindolines

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