Stereoselective synthesis of fluoroalkylated (Z)-alkene via nickel-catalyzed and iron-mediated hydrofluoroalkylation of alkynes

文献情報

出版日 2021-09-24

DOI 10.1039/D1QO00983D

インパクトファクター 5.281

著者

Xiang-Rui Li, Wen-Xin Li, Zhuo-Wen Zhang, Chuanji Shen, Xiaocong Zhou, Xue-Qiang Chu, Weidong Rao, Zhi-Liang Shen

原文を見る

要旨

An efficient nickel-catalyzed, iron-mediated hydrofluoroalkylation of alkynes with bromodifluoroacetate or perfluoroalkyl iodide was developed. The reactions proceeded efficiently via a radical reaction pathway to give fluoroalkylated (Z)-alkenes in moderate to good yields with good control of stereoselectivity (up to 99 : 1 Z/E), exhibiting both wide substrate scope and broad functional group tolerance. In addition, the method also entailed the easy functionalization of alkyne-tethered complex molecules derived from sugars and pharmaceuticals.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Stereoselective synthesis of fluoroalkylated (Z)-alkene via nickel-catalyzed and iron-mediated hydrofluoroalkylation of alkynes

文献情報

おすすめジャーナル

関連文献

Computational insight into the halogen bonded self-assembly of hexa-coordinated metalloporphyrins

Microstructural dependent oxygen reduction reaction in a Ruddlesden–Popper perovskite (SmSr)NiO4−δ

Multimode binding and stimuli responsive displacement of acridine orange dye complexed with p-sulfonatocalix[4/6]arene macrocycles

Correlation effects in parallel tempering and the role of the swapping frequency

Tailoring the protonic conductivity of porous yttria-stabilized zirconia thin films by surface modification

Influence of alkaline-earth metal substitution on structure, electrical conductivity and oxygen transport properties of perovskite-type oxides La0.6A0.4FeO3−δ (A = Ca, Sr and Ba)

Analytical magnetostatic model for 2D arrays of interacting magnetic nanowires and nanotubes

Mixed uranyl and neptunyl cation–cation interaction-driven clusters: structures, energetic stability, and nuclear quadrupole interactions

Water structures on a Pt(111) electrode from ab initio molecular dynamic simulations for a variety of electrochemical conditions

Predicting the phase diagram of titanium dioxide with random search and pattern recognition

こちらもおすすめ

除水剤ALT-201は安全ですか？

「邻羟基阿托伐他汀内酯标准品」に適用される法規ガイドelinesは何ですか？

メチル（3R）-3-アミノ-2,3-ジヒドロ-1-ベンゾファンラニン-5-カルボイル酸塩塩酸塩の主な用途は何ですか？

トランス-4-メチルピロリジン-3-オール塩酸塩はどのように合成されますか？

硫雜環丁烷-1,1-二氧化物は安全ですか？

ブラエリリンの主な用途は何ですか？

9-ヒドロキシエリプチシネ塩酸塩はどのように合成されますか？

5-塩素-2-(メチルアミノ)フェニル-(2-塩素フェニル)メタン酮の物理化学的性質は何ですか？

1-[2-(4-甲氧基-苯氧基)-乙基]-哌嗪はどのように保存すればよいですか？

2-[3-(4-甲氧基フェニル)プロピル]-4,4,5,5-四メチル-1,3,2-ドイボロロールアンの主な用途は何ですか？

掲載誌

Organic Chemistry Frontiers

おすすめ化合物

N3-ethylpyridine-3,4-diamine

2-Sulfanyl-3-pentanone

ent-Lurasidone Hydrochloride

1-(1,3-Thiazol-4-yl)ethanamine

Methyl 2-hydroxydodecanoate

おすすめサプライヤー