Palladium-catalyzed cyanation of aryl halides with in situ generated CN− from ClCF2H and NaNH2

文献情報

出版日 2020-08-19

DOI 10.1039/D0QO00775G

インパクトファクター 5.281

著者

Changjiang Yu, Xingxing Ma, Qiuling Song

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要旨

An efficient Pd-catalyzed cyanation of aryl halides with in situ generated CN− anions is described. The CN− source stems from the quadruple cleavage of chlorodifluoromethane (ClCF2H) with sodium amide (NaNH2). This transformation features no requirement of a toxic CN source and avoids the problem of HCN generation associated with traditional methods. A series of aryl nitriles are obtained from aryl halides in good yields under mild reaction conditions.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Palladium-catalyzed cyanation of aryl halides with in situ generated CN− from ClCF2H and NaNH2

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