Synthesis of polysubstituted quinolines through promoter-regulated selective annulation and C–C bond cleavage from 2-styrylanilines and β-keto esters

文献情報

出版日 2020-07-01

DOI 10.1039/D0QO00709A

インパクトファクター 5.281

著者

Hui Xu, Fei Yu, Ronglu Huang, Mingyue Weng, Hong Chen, Ze Zhang

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要旨

A powerful construction of 2-alkylquinolines and quinoline-2-carboxylates has been successfully accomplished employing I2 and Mn(OAc)3, respectively, to promote the annulation of 2-styrylanilines and β-keto esters accompanied by selective C–C bond cleavage. Following this promoter-regulated strategy, various 2-alkylquinolines and quinoline-2-carboxylates were chemoselectively synthesized from easily available 2-styrylanilines and β-keto esters. The reaction mechanism is also tentatively investigated.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis of polysubstituted quinolines through promoter-regulated selective annulation and C–C bond cleavage from 2-styrylanilines and β-keto esters

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