Development and disassembly of single and multiple acid-cleavable block copolymer nanoassemblies for drug delivery

文献情報

出版日 2020-03-31

DOI 10.1039/D0PY00234H

インパクトファクター 5.582

著者

Arman Moini Jazani, Jung Kwon Oh

原文を見る

要旨

Drug delivery via block copolymer nanoassemblies has been widely viewed as an efficient way to augment therapeutic efficiency of anticancer drugs for cancer therapy. Acid-degradable block copolymer-based nanoassemblies are promising intracellular candidates for tumor-targeting drug delivery as they exhibit enhanced release of encapsulated drugs through their dissociation (or disintegration) upon cleavage of acid-labile linkages in response to a tumor's acidic environment (pH = 4.2–6.7). Furthermore, degradation of the self-assemblies via acid-catalyzed hydrolysis can be tuned with a choice of various available acid-labile linkages. This review summarizes recent advances in the synthesis and disassembly of acid-cleavable block copolymers for controlled drug delivery. Strategies to integrate acid-labile covalent linkages in block copolymers at different locations, as in micelle cores and core/corona interfaces are particularly focused upon. Additionally, elegant strategies that allow for the synthesis of dual acid/reduction, acid/light, acid/enzyme-degradable block copolymer systems with cleavable linkages in single or dual locations are discussed.

関連文献

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

Ronel Müller, Tiaan M. Gerwel, Magambo Phillip Kimuda, Özlem Tastan Bishop, Clinton G. L. Veale, Heinrich C. Hoppe

2021-08-23 Research Article

DOI: 10.1039/D1MD00237F

Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses

Sahil Mishra, Shreya

2020-12-23 Review Article

DOI: 10.1039/D0MD00318B

Recent advances in the development of AHR antagonists in immuno-oncology

2021-04-06 Review Article

DOI: 10.1039/D1MD00015B

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance

Ankita Punetha, Keith D. Green, Atefeh Garzan, Nishad Thamban Chandrika, Melisa J. Willby, Allan H. Pang, Caixia Hou, Selina Y. L. Holbrook, Kyle Krieger, James E. Posey, Tanya Parish, Oleg V. Tsodikov, Sylvie Garneau-Tsodikova

2021-10-05 Research Article

DOI: 10.1039/D1MD00239B

Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer

Nelson A. M. Pereira, Bruno F. O. Nascimento, João Pina, Gonçalo Brites, J. Sérgio Seixas de Melo, Marta Pineiro, Teresa M. V. D. Pinho e Melo

2021-04-14 Research Article

DOI: 10.1039/D0MD00433B

Retraction: MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization

2021-01-26 Retraction

DOI: 10.1039/D1MD90001C

Profiling MAP kinase cysteines for targeted covalent inhibitor design

Ruibin Liu, Neha Verma, Jack A. Henderson, Shaoqi Zhan, Jana Shen

2021-11-03 Research Article

DOI: 10.1039/D1MD00277E

Target 2035 – update on the quest for a probe for every protein

Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Hartmut Beck, Shaunna Beedie, Ulrich A. K. Betz, Gustavo Arruda Bezerra, Paul E. Brennan, David Brown, Peter J. Brown, Alex N. Bullock, Adrian J. Carter, Apirat Chaikuad, Mathilde Chaineau, Alessio Ciulli, Ian Collins, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Stephen M. Fuchs, Matthew D. Hall, Ingo V. Hartung, Alexander Hillisch, Stephen H. Hitchcock, Evert Homan, Natarajan Kannan, James R. Kiefer, Stefan Knapp, Milka Kostic, Stefan Kubicek, Andrew R. Leach, Sven Lindemann, Hisanori Matsui, Jordan L. Meier, Maurice Michel, Maxwell R. Morgan, Anke Mueller-Fahrnow, Dafydd R. Owen, Benjamin G. Perry, Saul H. Rosenberg, Kumar Singh Saikatendu, Cora Scholten, Sujata Sharma, Anton Simeonov, Michael Sundström, Matthew H. Todd, Claudia Tredup, Timothy M. Willson, Georg E. Winter

2021-12-03 Opinion

DOI: 10.1039/D1MD00228G

Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs

Utsav Garg, Yasser Azim

2021-02-09 Review Article

DOI: 10.1039/D0MD00400F

Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties

Ivana Cacciatore, Hasan Turkez, Annalisa Di Rienzo, Michele Ciulla, Antonio Di Stefano

2021-08-13 Research Article

DOI: 10.1039/D1MD00177A

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Development and disassembly of single and multiple acid-cleavable block copolymer nanoassemblies for drug delivery

文献情報

おすすめジャーナル

関連文献

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses

Recent advances in the development of AHR antagonists in immuno-oncology

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance

Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer

Retraction: MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization

Profiling MAP kinase cysteines for targeted covalent inhibitor design

Target 2035 – update on the quest for a probe for every protein

Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs

Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties

こちらもおすすめ

カルボニル基が付いた5-氰基-1-{[(2-メチル-2-プロpanyl)オキシ]カーボンイル}1H-吲哚-2-イリド-2-ボリン酸はどのように保存すればよいですか？

tert-ブチル2-クロロメチルピリジン-3-基炭酸エステルの市場動向や研究トレンドはどうですか？

聚二季戊四醇六丙烯酸酯はどの業界で使用されていますか？

1-氯-5-硝基异喹啉の市場動向や研究トレンドはどうですか？

2-チロール-5-メチルスルフェニル-3-trifルオルメチルベンゼンはどのように合成されますか？

p-トールイルマグネシウムブロミドの物理化学的性質は何ですか？

1-(5-甲基-2-硫化素基)プロパン-1-酮の市場動向や研究トレンドはどうですか？

十一碳烯酰甘氨酸を取り扱う際の実験室安全事項は何ですか？

1H,1H-全氟-3,6-二氧杂葵-1-醇を取り扱う際の実験室安全事項は何ですか？

3-(4-(フルオロメチルオキシ)フェニル)-1,2,4-オキサジアゾール-5-カルボハイドライドは安全ですか？

掲載誌

Polymer Chemistry

おすすめ化合物

5,6-Difluoro-indan-2-one

Benzyl 2-{[(tert-butoxy)carbonyl]amino}acetate

4-Bromo-5,7-difluoro-1H-indole

Allopregnanolone Sulfate

1-(2-Chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

おすすめサプライヤー