Rh-Catalyzed C–H activation/intramolecular condensation for the construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines

文献情報

出版日 2020-03-20

DOI 10.1039/D0OB00382D

インパクトファクター 3.876

著者

Yi Ning, Xinwei He, Youpeng Zuo, Jian Wang, Qiang Tang, Mengqing Xie, Ruxue Li, Yongjia Shang

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要旨

A novel and mild Rh(III)-catalyzed C–H activation/intramolecular condensation of 1-aryl-1H-pyrazol-5-amines with cyclic 2-diazo-1,3-diketones was developed, giving access to various important benzo[f]pyrazolo[1,5-a][1,3]diazepine scaffolds through sequential C–C/C–N bond formation in a one-pot procedure under additive- and oxidant-free conditions. Furthermore, 3-([1,1′-biphenyl]-2-ylamino)-2-ethoxycyclohex-2-enones can be obtained in good yields by constructing C–O and C–N bonds through 1,1′-insertion, dehydration, and isomerization processes.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Rh-Catalyzed C–H activation/intramolecular condensation for the construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines

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