Copper-catalyzed synthesis of trifluoromethylated bis(indolyl)arylmethanes from 2-arylindoles and 2,2,2-trifluoroacetohydrazide

文献情報

出版日 2019-12-19

DOI 10.1039/C9QO01131E

インパクトファクター 5.281

著者

Zihang Yuan, Shouxiong Chen, Zhiqiang Weng

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要旨

One-pot synthesis of trifluoromethylated bis(indolyl)arylmethanes through copper-catalyzed reaction of 2-arylindoles with 2,2,2-trifluoroacetohydrazide is described. This viable transformation provides a variety of 3,3′-bis(indolyl)methanes with a CF3-containing tertiary carbon center in moderate to good yields. Preliminary mechanistic studies revealed that the reaction involves the in situ generation of a trifluoroacetyl radical and trapping with 2-arylindoles.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-catalyzed synthesis of trifluoromethylated bis(indolyl)arylmethanes from 2-arylindoles and 2,2,2-trifluoroacetohydrazide

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