Controlling release kinetics of pH-responsive polymer nanoparticles

文献情報

出版日 2020-01-24

DOI 10.1039/C9PY01946D

インパクトファクター 5.582

著者

Naruphorn Dararatana, Farzad Seidi, Juliette Hamel, Daniel Crespy

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要旨

Polymers with pH-responsive properties are well-known in biomedical applications. We design here polymers that can release payloads upon acidification of their immediate environment. Various corrosion inhibitors such as benzotriazole-5-carbohydrazide, 5-(aminomethyl)-8-hydroxyquinoline, and tryptamine are conjugated to copolymers via imine or hydrazone linkages. Polymer-corrosion inhibitor conjugates displayed a faster release rate of the inhibitor under acidic conditions compared to neutral conditions. Release profiles were controlled by the type of the labile linkage, the nature of the corrosion inhibitor, and by the spacer length.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Controlling release kinetics of pH-responsive polymer nanoparticles

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