On the impossibility of determination of stepwise binding constants for the 1 ∶ 2 complex of (+)-camphor with α-cyclodextrin

文献情報

出版日 2003-01-13

DOI 10.1039/B209272G

インパクトファクター 3.876

著者

Helena Dodziuk, Krzysztof S. Nowinski, Wiktor Kozminski, Grigory Dolgonos

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要旨

Knowledge of stepwise binding constants for complexes with higher than 1 ∶ 1 stoichiometry would allow one to study the cooperativity of their formation. However, a detailed analysis of partitioning of the overall binding constant β12 determined by NMR titrations for the 1 ∶ 2 complex of (+)-camphor with α-cyclodextrin into the stepwise ones K1 and K2 carried out analogously to published procedures revealed that the partitioning cannot be carried out unequivocally for K1 << K2. The programs for partitioning cannot be used as a black box and a satisfactory reproduction of the experimental dependence of relative shifts as a function of relative CD concentration should not be the only criterion of the reliability of the stepwise binding constants obtained using such programs.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

On the impossibility of determination of stepwise binding constants for the 1 ∶ 2 complex of (+)-camphor with α-cyclodextrin

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