Facile access to 1,3-diketones by gold(i)-catalyzed regioselective hydration of ynones

文献情報

出版日 2019-03-25

DOI 10.1039/C9OB00494G

インパクトファクター 3.876

著者

Tao Zhou, Tingjie You, Jianhui Chen, Chenliang Su, Yuanzhi Xia

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要旨

A facile and efficient synthesis of 1,3-diketones was developed by the gold(I)-catalyzed regioselective hydration of ynones at room temperature. This methodology employed 2.5 mol% of PPh3AuCl and 3 mol% of AgOTf as a simple catalytic system without any special phosphine ligand and was compatible with a wide range of substrates, giving rise to 1,3-diaryl, 1-alkyl-3-aryl-, and 1,3-dialkyl-1,3-diketones in up to quantitative yields in open flask reactions. This methodology could be readily scaled up to gram-scales.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Facile access to 1,3-diketones by gold(i)-catalyzed regioselective hydration of ynones

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