Chemical synthesis of glycosaminoglycan-mimetic polymers

文献情報

出版日 2018-10-14

DOI 10.1039/C8PY01338A

インパクトファクター 5.582

著者

Hong Chen

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要旨

Glycosaminoglycans (GAGs) are mammalian cell-secreted linear polysaccharides that participate in many critical physiological processes via their interactions with a variety of proteins. Unfortunately natural GAGs have disadvantages that hinder their use in cell-based therapy and tissue engineering. GAG-mimetic polymers represent alternatives to natural GAGs, and studies on the preparation of these polymers have appeared in recent years. This review describes several general chemical approaches for the preparation of GAG-mimetic polymers based on different backbones and sidechains, and highlights the importance of these synthetic GAG-mimetic polymers in controlling key biofunctions. The prospects for further advances in the development of synthetic GAG-mimetic polymers are also discussed.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Chemical synthesis of glycosaminoglycan-mimetic polymers

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