Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer
文献情報
Alicia Megia-Fernandez, Bethany Mills, Chesney Michels, Sunay V. Chankeshwara, Nikola Krstajić, Chris Haslett, Kevin Dhaliwal, Mark Bradley
Optical biosensing based on the activation of fluorescent reporters offers a powerful methodology for the real-time molecular interrogation of pathology. Here we report a first-in-class, bimodal fluorescent reporter strategy for the simultaneous and highly specific detection of two independent proteases (thrombin and matrix metalloproteases (MMPs)) pivotal in the fibroproliferative process surrounding lung cancer, based on a dual, multiplexing, peptide FRET system. This sophisticated synthetic smartprobe, with a molecular weight of 6 kDa, contains two independent fluorophores and quenchers that generate photonic signatures at two specific wavelengths upon activation by target enzymes within human lung cancer tissue.
関連文献
Stability of metallo-porphyrin networks under oxygen reduction and evolution conditions in alkaline media
Diana Hötger, Markus Etzkorn, Benjamin Wurster, Jan Dreiser, Sebastian Stepanow, Doris Grumelli, Rico Gutzler
DOI: 10.1039/C8CP07463A
Correction: Surface induced smectic order in ionic liquids – an X-ray reflectivity study of [C22C1im]+[NTf2]−
Henning Weiss, Hailong Li, Oleg Konovalov, Sven Festersen, Uta Rütt
DOI: 10.1039/C8CP91851A
Amplified spontaneous emission in phenylethylammonium methylammonium lead iodide quasi-2D perovskites
DOI: 10.1039/C8CP02133C
Model – free approach to quadrupole spin relaxation in solid 209Bi-aryl compounds
Danuta Kruk, Christian Goesweiner, Elzbieta Masiewicz, Evrim Umut, Carina Sampl, Hermann Scharfetter
DOI: 10.1039/C8CP03848A
Lithium doped tubular structure in LiB20 and LiB20−: a viable global minimum
Wei-yan Liang, Anita Das, Xue Dong, Zhong-hua Cui
DOI: 10.1039/C8CP01376D
Effect of nano-pillared surfaces with an arrangement density gradient on droplet coalescence dynamics
Tao Li, MingYu Li, JunJun Wang, Jie Li, YunRui Duan, Hui Li
DOI: 10.1039/C8CP05014G
Machine learning for predicting product distributions in catalytic regioselective reactions
Sayan Banerjee, A. Sreenithya, Raghavan B. Sunoj
DOI: 10.1039/C8CP03141J
Dynamics in a one-dimensional ferrogel model: relaxation, pairing, shock-wave propagation
DOI: 10.1039/C8CP01395K
Electro-analytical investigation of potential induced degradation in mc-silicon solar cells: case of sodium ion induced inductive loop
Zeel Purohit, Deepak Verma, Brijesh Tripathi
DOI: 10.1039/C8CP02703J
こちらもおすすめ
6-苄基-6,7-二氢-5H-吡咯并3,4-b吡啶とは何ですか?
6-苄基-6,7-二氢-5H-吡咯并3,4-b吡啶は、CAS番号109966-30-5の化合物です。これは、6-ベンジル基を持つ6,7-二氢-5H-吡咯並みの化...
半硫酸奎宁单水水合物はどのように保存すればよいですか?
半硫酸奎宁单水水合物は、乾燥した涼しい場所に保管し、直射日光や湿気を避ける必要があります。保存温度は常温(15〜25℃)が適切で、湿度は40%以下を維持すること...
D-核糖-5-リン酸二ナトリウムとは何ですか?
D-核糖-5-リン酸二ナトリウムは、CAS番号18265-46-8を有する化合物で、D-核糖の5位付加部位にリン酸基が結合した化合物です。この化合物は、水溶性で...
3-乙酰基-4-羟基喹啉-2(1H)-酮はどのように合成されますか?
3-乙酰基-4-羟基喹啉-2(1H)-酮は、ハイドロキノンと酢酸アセトイルアミドのアミド化反応により合成されます。この反応は塩基触媒を用いて行われ、選択性は良好...
5-溴-4-甲基-1H-吲唑とは何ですか?
5-溴-4-甲基-1H-吲唑は、CAS番号1082041-34-6の化学物質で、化学式はC10H9BrNです。この化合物は淡黄色の結晶性粉末で、吸湿性があります...
3-(4メトキシフェニル)オキテナン-3カーボイル酸の代替品はありますか?
3-(4メトキシフェニル)オキテナン-3カーボイル酸の代替品は、その用途により異なりますが、例えば4-(メトキシフェニル)オキテナン-3カーボイル酸や、他のオキ...
3-イリドオキシピロロ[2,3-b]ピリジン-5-カルボキシlic酸は安全ですか?
3-イリドオキシピロロ[2,3-b]ピリジン-5-カルボキシlic酸は危険な化合物ではありませんが、適切な手袋や保護眼鏡の使用を推奨します。誤って摂取または接触...
3-氟-4- iodobenolを取り扱う際の実験室安全事項は何ですか?
3-氟-4- iodobenolは可燃性を有し、強力な反応性を持つため、取り扱いには注意が必要です。PPE(個人保護具)の着用、ドラフトチャンバーの使用、漏洩時...
掲載誌
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.














