Tsavoenones A–C: unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense
文献情報
Mehdi A. Beniddir, Grégory Genta-Jouve, Thammarat Aree, Marylène Chollet-Krugler, Joël Boustie, Solenn Ferron, Aurélie Sauvager, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Warinthorn Chavasiri, Pierre Le Pogam
New racemic dispiranic polyketides, tsavoenones A (1), B (2) and C (3), having a novel 1,7-dioxadispiro[4.0.4.4]tetradecane scaffold were isolated from the foliose lichen Parmotrema tsavoense. These compounds were structurally elucidated by extensive NMR analyses, comparison between experimental and theoretical 13C NMR data and X-ray crystallography. A putative biosynthetic scenario for the formation of 1–3 from parmosidone D, a meta-depsidone previously isolated from the same lichen material, was proposed. Tested for its cytotoxicity, 1 displayed a moderate activity against human myelogenous leukemia K562 cell line with an IC50 value of 66 μg mL−1.
関連文献
Theoretical study of the mechanism of the solvent dependency of ESIPT in HBT
Keiji Naka
DOI: 10.1039/D0CP06604D
Origin of the hydrophobicity of sulfur-containing iron surfaces
Hao Li, Weijie Yang, Chongchong Wu, Jiang Xu
DOI: 10.1039/D1CP00588J
Controlled 2H/1T phase transition in MoS2 monolayers by a strong interface with M2C MXenes: a computational study
Zhongxu Wang, Yu Liu, FengYu Li, Jingxiang Zhao
DOI: 10.1039/D1CP02648H
Surface hopping dynamics reveal ultrafast triplet generation promoted by S1–T2–T1 spin-vibronic coupling in 2-mercaptobenzothiazole
Chithra M. J., Probal Nag, Sivaranjana Reddy Vennapusa
DOI: 10.1039/D1CP02587B
Doping of the hydrogen-passivated Si(100) electronic structure through carborane adsorption studied using density functional theory
Martin Hladík, Antonín Fejfar, Héctor Vázquez
DOI: 10.1039/D1CP01654G
Atmospheric oxidation of fluoroalcohols initiated by ˙OH radicals in the presence of water and mineral dusts: mechanism, kinetics, and risk assessment
Feng-Yang Bai, Ming-Shuai Deng, Mei-Yan Chen, Lian Kong, Shuang Ni, Xiu-Mei Pan
DOI: 10.1039/D1CP01324F
Molecular properties affecting the hydration of acid–base clusters
Deanna Myers, Sabrina Chee, James N. Smith
DOI: 10.1039/D1CP01704G
Self-consistent field modeling of mesomorphic phase changes of monoolein and phospholipids in response to additives
N. de Lange, J. M. Kleijn, F. A. M. Leermakers
DOI: 10.1039/D1CP00697E
Interfacial photoinduced carrier dynamics tuned by polymerization of coronene molecules encapsulated in carbon nanotubes: bridging type-I and type-II heterojunctions
Xiao-Ying Xie, Jia-Jia Yang, Xiang-Yang Liu, Qiu Fang, Wei-Hai Fang, Ganglong Cui
DOI: 10.1039/D1CP01008E
Effects of molecular shape on alcohol aggregation and water hydrogen bond network behavior in butanol isomer solutions
Seungeui Choi, Saravanan Parameswaran, Jun-Ho Choi
DOI: 10.1039/D1CP00634G
こちらもおすすめ
3-イチチルビフェニルはどのように合成されますか?
3-イチチルビフェニルは、ビフェニルとイチプロピオニトリルを回収率約90%で反応させて合成されます。触媒は通常、亜リチウムホウ素を用います。
8-溴-5-三氟甲基喹啉はどのように合成されますか?
8-溴-5-三氟甲基喹啉は、5-トリフルオロメチル-2-メチル-1,3-ベンゼンジオールをブロモエタノールと反応させて生成します。この反応は塩基性条件下で行われ...
ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか?
ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品としては、4-...
N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか?
N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向は、主に産業用途での需要により影響を受けます。研究トレンドとし...
イソステアロイルグリセリルは安全ですか?
イソステアロイルグリセリルは一般的に安全性が高いとされていますが、過度な使用や個人差により皮�owsん炎などの反応が起こる可能性があります。使用前に医師に相談す...
1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか?
1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向は、医薬品や合成化学の研究分野で注目を集めています。新興研究は、該当化合物の合成改良と生体内での作用メカニズ...
3-チオフェンスチオールの物理化学的性質は何ですか?
3-チオフェンスチオールのCAS番号は7774-73-4です。結晶性の白色粉末で、分子量は122.17です。この化合物は水に微溶解し、エタノールやジクロロメタン...
2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか?
2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは一定の安全性基準を満たしていま...
CAS番号1316822-90-8の化合物は安全ですか?
CAS番号1316822-90-8の化合物は安全性に関しては評価が不足していますが、一般的には生物学的に活性な物質であり、取り扱いには適切な安全防護措置が必要で...
Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか?
Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸は、冷暗所で保存し、直射日光から遠ざけてください。容器は密閉し、高湿度や高温を避けて保管してください。
掲載誌
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.













![1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure 1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure](https://static.chemtradehub.com/structs/914/914637-08-4-8825.webp)
