Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

文献情報

出版日 2016-10-05

DOI 10.1039/C6PY01644H

インパクトファクター 5.582

著者

Andrea Cappelli, Marco Paolino, Giorgio Grisci, Vincenzo Razzano, Germano Giuliani, Alessandro Donati, Claudia Bonechi, Raniero Mendichi, Salvatore Battiato, Filippo Samperi, Cinzia Scialabba, Gaetano Giammona, Francesco Makovec

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要旨

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material bearing HA on the surface of its cylindrical brush architecture showed promising prerequisites for the preparation of nanostructured drug delivery systems.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

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