A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery

文献情報

出版日 2015-04-17

DOI 10.1039/C5PY00466G

インパクトファクター 5.582

著者

Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam, Peihong Ni

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要旨

Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC-g-PEEP) were synthesized through a “grafting onto” process, in which a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry was utilized. The resulting suspension of negatively-charged CNC-g-PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A new pathway towards polymer modified cellulose nanocrystals via a “grafting onto” process for drug delivery

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Polymer Chemistry

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