An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

文献情報

出版日 2014-04-01

DOI 10.1039/C4PY00207E

インパクトファクター 5.582

著者

Kelly A. Gilmore

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要旨

Polyester nanosponges were prepared with varied degrees of crosslinking densities of ∼4%, ∼7% and ∼10% and an average nanoscopic size of 100 nm. The crosslinking density and the influence towards the release kinetics of paclitaxel, a BCS class IV drug, for individual particles and a mixture of particles with two different crosslinking densities are investigated in buffer and gastrointestinal fluid to show fully adjustable release rates suitable for intravenous and oral delivery.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

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