Copper–amyloid-β complex may catalyze peroxynitrite production in brain: evidence from molecular modeling
文献情報
Ilaria Ciofini, Li Rao, Christian Amatore
Rationalization of the origin of peroxynitrite-related damages in the brain of Alzheimer's disease (AD) patients linking to functional hyperemia, inexplicable on the basis of the accepted hydrogen peroxide catalytic route, is here provided by molecular modeling. The present theoretical work indeed strongly supports the facile occurrence of an Aβ-catalyzed generation of peroxynitrite in the brain, alternative to the already accepted H2O2-route, whenever ascorbate, dioxygen and nitric oxide are present near Cu–Aβ complexes without the necessity of generating short-lived superoxide ions. The proposed route requires nitric oxide and dioxygen to be simultaneously present at sufficiently high concentrations near Cu–Aβ complexes, requirement which is frequently fulfilled in brain during functional hyperemia. Conversely, hydrogen peroxide would be produced during resting phases.
おすすめジャーナル
関連文献
A catenane consisting of a large ring threaded through both cyclic units of a handcuff-like compound
Julien Frey, Tomáš Kraus, Valérie Heitz, Jean-Pierre Sauvage
DOI: 10.1039/B509745B
Synthesis, structure, and olefinpolymerization with nickel(ii) N-heterocyclic carbene enolates
Benjamin E. Ketz, Xavier G. Ottenwaelder, Robert M. Waymouth
DOI: 10.1039/B511202H
A new alternative to Stryker's reagent in hydrosilylation: synthesis, structure, and reactivity of a well-defined carbene–copper(ii) acetate complex
Jaesook Yun, Daesung Kim, Hoseop Yun
DOI: 10.1039/B509964A
ortho-Hydroxylation of benzoic acids with hydrogen peroxide at a non-heme iron center
Sonia Taktak, Margaret Flook, Bruce M. Foxman, Lawrence Que, Jr., Elena V. Rybak-Akimova
DOI: 10.1039/B508004E
Demonstration of the optical limiting effect for an hemiporphyrazine
Danilo Dini, Mario J. F. Calvete, Michael Hanack, Vincenzo Amendola, Moreno Meneghetti
DOI: 10.1039/B601591C
A novel mediatorless microbial fuel cell based on direct biocatalysis of Escherichia coli
Tian Zhang, Changzheng Cui, Shengli Chen, Xinping Ai, Hanxi Yang, Ping Shen, Zhenrong Peng
DOI: 10.1039/B600876C
Achiral benzophenoneligand–rhodium complex with chiral diamine activator for high enantiocontrol in asymmetric transfer hydrogenation
Koichi Mikami, Kazuki Wakabayashi, Yukinori Yusa, Kohsuke Aikawa
DOI: 10.1039/B517585B
The unexpected similar second-order NLO response for nearly planar and largely twisted push–pull stilbazole chromophores: EFISH and theoretical TD-DFT evidence
Filippo De Angelis
DOI: 10.1039/B509258B
Towards large amounts of Janusnanoparticles through a protection–deprotection route
Stéphane Reculusa, Franck Pereira, Marie-Hélène Delville, Christophe Mingotaud, Etienne Duguet, Elodie Bourgeat-Lami, Serge Ravaine
DOI: 10.1039/B507486J
こちらもおすすめ
S-(甲硅烷基丙基)異硫酰氯を取り扱う際の実験室安全事項は何ですか?
取り扱う際にはPPE(防護具)が必要です。特に手袋と面マスクは必須です。ドラフトチャンバーを使用して漏洩処理を行い、温度は常温、湿度は乾燥状態、容器はガラス容器...
8-硝基-咪唑并[1,2-a]吡啶とは何ですか?
8-硝基-咪唑并[1,2-a]吡啶は、CAS番号52310-46-0の化合物で、8-位に硝基を有する咪唑並みの结构をもつ吡啶の化合物です。この化合物は、酸化還元...
4-ブロモ-5-メトキシピリジン-2-甲醇の代替品はありますか?
4-ブロモ-5-メトキシピリジン-2-甲醇の代替品には、類似構造を持つ化合物や機能性に等しい代替試薬があります。例えば、4-クロロ-5-メトキシピリジン-2-甲...
全氟-1,2-二甲基環己烷を含む廃棄物はどのように処理すべきですか?
全氟-1,2-二甲基環己烷(CAS番号:306-98-9)の廃棄物は、特別な処理が必要です。まず、廃棄物を密閉容器に収集し、適切な防漏容器に保管します。次に、専...
3-(溴甲基)苯乙酸の主な用途は何ですか?
3-(溴甲基)苯乙酸は主に研究用化学薬品として利用され、有機合成や医薬品の開発に用いられます。また、特定の化合物の合成中間体としても使用されることがあります。
5-イドキド-4-メチオキシ-6-メチルピリミジニン-2-アミンはどのように保存すればよいですか?
5-イドキド-4-メチオキシ-6-メチルピリミジニン-2-アミンは冷暗所で密栓の容器に保存し、直射日光を避けて保管することをお勧めします。温度は常温とし、湿気を...
1-(2-溴-6-甲氧基苯基)乙酮を取り扱う際の実験室安全事項は何ですか?
実験室では、1-(2- Bromo-6-methoxyphenyl)ethanoneを取り扱う際には、ゴーグルや面具、手袋などのPPEを使用することが推奨されま...
5-(4,4,5,5-テトラメチル-1,3,2-ダイオキサボラロール-2-イル)-1,3-ジヒドロ-2-ベンゾフランは安全ですか?
5-(4,4,5,5-テトラメチル-1,3,2-ダイオキサボラロール-2-イル)-1,3-ジヒドロ-2-ベンゾフランは一般に安全ですが、取扱いには注意が必要です...
4-溴萘-1-甲酸の代替品はありますか?
4-溴萘-1-甲酸は比較的稀な化合物ですが、類似物としては、4-クロロ-1-ナフホリック酸やその他のブロモ置換ナフホリック酸が挙げられます。ただし、これらの代替...
ε-白藜芦醇脱氢二聚体の代替品はありますか?
ε-白藜芦醇脱氢二聚体の代替品としては、ε-白藜芦醇、ポリフェノール類、フラボノイド類が挙げられます。これらは類似の化学構造と生物学的活性を持っています。ただし...
掲載誌
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine structure N-[(9H-Fluoren-9-ylmethoxy)carbonyl]serine structure](https://static.chemtradehub.com/structs/737/73724-45-5-b0dc.webp)