Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation

文献情報

出版日 2012-04-18

DOI 10.1039/C2PY20154B

インパクトファクター 5.582

著者

Samuel Aleksanian, Behnoush Khorsand, Rolf Schmidt, Jung Kwon Oh

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要旨

Degradation of amphiphilic block copolymer (ABP) micelles in response to external stimuli (stimuli-responsive degradation) is a desired property in the design of controlled delivery vehicles. Here, a versatile methodology that combines facile carbodiimide coupling polycondensation with controlled radical polymerization to synthesize thiol-responsive degradable ABP micelles is described. These smart micelles consist of a hydrophobic degradable polyester block with disulfide linkages labeled repeatedly along the main chain; more importantly, in response to thiols they exhibit rapid and controlled degradation, thereby leading to enhanced release of encapsulated model drugs. Moreover, the proposed method allows for a facile bioconjugation of hydrophilic coronas using cell-targeting biomolecules during polymerization.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation

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