Polyethyleneimine functionalized polymer microsphere: a novel delivery vector for cells

文献情報

出版日 2012-02-23

DOI 10.1039/C2PY20012K

インパクトファクター 5.582

著者

Chunying Gao, Han Zhang, Ming Wu, Yang Liu, Yipan Wu, Xinlin Yang, Xizeng Feng

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要旨

Monodisperse poly(ethylene glycol dimethacrylate-co-methacrylic acid) (P(EGDMA-co-MAA)) microspheres with two different diameters (69 and 160 nm) were facilely synthesized via distillation precipitation polymerization in neat acetonitrile, and these microspheres interacted with the amino groups of polyethyleneimine (PEI) chains though hydrogen-bonding as well as electrostatic interactions to form PEI-functionalized (P(EGDMA-co-MAA)). The successful modification of P(EGDMA-co-MAA) microspheres with PEI was confirmed by dynamic light scattering (DLS) and agarose gel electrophoresis. The in vitro gene transfection was evaluated by co-culturing human embryonic kidney (HEK) 293T cells and P(EGDMA-co-MAA) microsphere/plasmid DNA (pDNA) complexes, and the results were determined by fluorescence microscopy. Furthermore, the cytotoxicity of PEI-functionalized P(EGDMA-co-MAA) microspheres was assessed via MTT assay and FDA–PI staining. The PEI-functionalized (P(EGDMA-co-MAA) provides a potential novel delivery vector for cells.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Polyethyleneimine functionalized polymer microsphere: a novel delivery vector for cells

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