Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

文献情報

出版日 2017-01-04

DOI 10.1039/C6PY01719C

インパクトファクター 5.582

著者

Sigen A, Qian Xu, Dezhong Zhou, Yongsheng Gao, Jeddah Marie Vasquez, Udo Greiser, Wenguang Liu

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要旨

Star-shaped poly(ethylene glycol)-N-hydroxysuccinimide (star-PEG-NHS) has shown great promise in a variety of biomedical applications owing to its non-toxicity, innate non-immunogenic properties and versatile, multifunctional end groups. However, its complex and sophisticated synthetic methods, as well as high costs, have significantly impeded its wide application. Here, we report the design and synthesis of a hyperbranched PEG-based polymer with multiple NHS functional groups (>12). The hyperbranched PEG-based multi-NHS polymer can react easily with a protein (bovine serum albumin, BSA) to form a PEG-protein hydrogel that displays great potential for biomedical applications.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

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