A near-infrared fluorescent probe for lipid hydroperoxides in living cells

文献情報

出版日 2008-05-15

DOI 10.1039/B802836B

インパクトファクター 4.616

著者

Ping Li, Bo Tang, Yanlong Xing, Puming Li, Guiwen Yang, Liang Zhang

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要旨

An NIR (near-infrared) fluorescent probe TCP (tricarbocyanine diphenylphosphine) including a non-conjugated ‘pre-tricarbocyanine’ was designed and synthesized for visualizing lipid hydroperoxides (ROOH) in living cells. The excitation and emission spectra of tricarbocyanine in the NIR region can effectively avoid background fluorescence interference in biological systems. The probe exhibited a rapid fluorescence response to ROOH and high selectivity for ROOH over other ROS (reactive oxygen species) and some biological compounds, and the limit of detection was 38 pM. In addition, the probe was stable, and less cytotoxic, which indicated that it has potential application in detecting lipid hydroperoxides in living biological systems.

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Analyst

CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A near-infrared fluorescent probe for lipid hydroperoxides in living cells

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