Supramolecular assembly-induced electrochemiluminescence enhancement of gold nanoclusters for hemoglobin detection

文献情報

出版日 2024-01-11

DOI 10.1039/D3TB02892E

インパクトファクター 6.331

著者

Xue Ge, Mingming Zhang, Fei Yin, Qian Sun, Fan Mo, Xinzhou Huang, Ying Zheng, Yuanjian Zhang

原文を見る

要旨

Gold nanoclusters (Au NCs) with excellent optical properties and biocompatibility have become one of the most promising electrochemiluminescence (ECL) emitters. However, the low efficiency and poor stability of Au NCs restrict their applications in ECL. Herein, by supramolecular assembly of L-arginine (Arg) and 4-hydroxy-2-mercapto-6-methylpyrimidine (MTU) on the surface of Au NCs, Arg/MTU-Au NCs with enhanced ECL efficiency and stability were prepared. Compared with the MTU-stabilized Au NCs (MTU-Au NCs), the ECL efficiency of Arg/MTU-Au NCs increased by 24.8 times. As a proof-of-concept, a sensitive biosensing platform was constructed for sensitive detection of hemoglobin (Hb) in urine using Arg/MTU-Au NCs as ECL emitters. The proposed ECL detection platform provides a feasible strategy for the detection of biomarkers in urine and has broad application prospects in disease screening and clinical marker detection.

掲載誌

Journal of Materials Chemistry B

CiteScore: 12

自己引用率: 4.9%

年間論文数: 831

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