Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

文献情報

出版日 2023-10-19

DOI 10.1039/D3RE00464C

インパクトファクター 4.239

著者

Dawid Drelinkiewicz, Tom J. A. Corrie, Richard J. Whitby

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要旨

In a continuous flow process, generating a gradient of solvent composition with time and monitoring of the reaction mixture as it leaves the reactor allows for rapid generation of reaction information against a full range of solvent mixture compositions. The methodology was developed by screening binary solvent mixtures in a SNAr reaction in which previously reported effects were efficiently reproduced. Binary and ternary solvent gradients were then applied to an imine forming reaction revealing interesting non-linear effects.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

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