Difluorocarbene as a C–F source for the construction of fluorinated benzothiazoles

文献情報

出版日 2023-11-13

DOI 10.1039/D3QO01422C

インパクトファクター 5.281

著者

Jiao Yu, Wei-Guo Cao, Ji-Chang Xiao

原文を見る

要旨

Difluorocarbene has served as a versatile intermediate for the incorporation of fluorinated groups into organic molecules. Extensive studies have shown that difluorocarbene can act as a CF2 source and a nonfluorinated C1 source. However, the use of difluorocarbene as a C–F source remains a challenging task. Herein we disclose that difluorocarbene can function as a C–F source for the cyclization of 2-aminobenzenethiols, allowing for the construction of fluorinated benzothiazoles, which may provide new possibilities for drug developments due to the magic effects of the fluorine element and the pharmacological properties of benzothiazoles.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Difluorocarbene as a C–F source for the construction of fluorinated benzothiazoles

文献情報

おすすめジャーナル

関連文献

Enzymatic synthesis of pharmacologically relevant chiral sulfoxides by improved CbBVMO variants

Liquid metal catalyzed chemical vapor deposition towards morphology engineering of 2D epitaxial heterostructures

Suppressed charge recombination via defect engineering of confined semiconducting quantum dots for photoelectrocatalysis

Boosting photocatalytic conversion of formic acid to CO over P-doped CdS

Back cover

Contributors to the Emerging Investigators collection 2023: Part 2

Trace-level chronopotentiometric detection in the presence of a high electrolyte background using thin-layer ion-selective polymeric membranes

Inside front cover

Photochemical reductive deamination of alpha-amino aryl alkyl ketones

Controlled assembly of photosensitizers through directional interactions for effective photooxidation

こちらもおすすめ

3-イチチルビフェニルはどのように合成されますか？

8-溴-5-三氟甲基喹啉はどのように合成されますか？

ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか？

N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか？

イソステアロイルグリセリルは安全ですか？

1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか？

3-チオフェンスチオールの物理化学的性質は何ですか？

2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか？

CAS番号1316822-90-8の化合物は安全ですか？

Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか？

掲載誌

Organic Chemistry Frontiers

おすすめ化合物

2,4-Dichloro-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one

6-Bromo-3-ethyl-3H-imidazo[4,5-b]pyridine

Imidazo[1,2-c]pyrimidine

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-6-carboxylic acid

Dehydroformouregine

おすすめサプライヤー