Direct electrochemical difluorination and azo-fluorination of gem-difluorostyrenes

文献情報

出版日 2023-11-22

DOI 10.1039/D3QO00599B

インパクトファクター 5.281

著者

Boao Li, Ziyan Zou, Naifu Zhou, Chengbo Sun, Pengju Feng, Hongsheng Li

原文を見る

要旨

Herein, a direct electrolysis protocol for the chemo- and regio-selective difluorination, azo-fluorination, and fluoro-alkoxylation of gem-difluorostyrenes under mild conditions is demonstrated. The reaction enables the selective synthesis of a distinct type of long-chain perfluoroalkyl aromatics involving Et3N·3HF as the fluorine source with/without other nucleophiles. The reaction exhibits good functional group tolerance, and is amenable to gram-scale synthesis. Moreover, an electrochemical reduction of the benzyl C–F bond was also achieved.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Direct electrochemical difluorination and azo-fluorination of gem-difluorostyrenes

文献情報

おすすめジャーナル

関連文献

Liquid metal–hydrogel composites for flexible electronics

Visible-light-enabled cascade cross-dehydrogenative-coupling/cyclization to construct α-chromone substituted α-amino acid derivatives

Iron-based fluorophosphate Na2FePO4F as a cathode for aqueous zinc-ion batteries

Recent progress in controlling the photoluminescence properties of single-walled carbon nanotubes by oxidation and alkylation

Inside front cover

Optimizing milling and sintering parameters for mild synthesis of highly conductive Li5.5PS4.5Cl1.5 solid electrolyte

Introduction of TiO2 enhancing the catalytic performance of Ti(SO4)2/SiO2 for dimethyl ether oxidation

Lead-oriented synthesis of epigenetic relevant scaffolds

Front cover

Artificial nucleotide codons for enzymatic DNA synthesis

こちらもおすすめ

3-イチチルビフェニルはどのように合成されますか？

8-溴-5-三氟甲基喹啉はどのように合成されますか？

ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか？

N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか？

イソステアロイルグリセリルは安全ですか？

1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか？

3-チオフェンスチオールの物理化学的性質は何ですか？

2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか？

CAS番号1316822-90-8の化合物は安全ですか？

Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか？

掲載誌

Organic Chemistry Frontiers

おすすめ化合物

9,9'-O-Isopropyllidene-isolariciresinol

Eichlerialactone

(4aR,5S,6R,8aS)-5-[2-(3-Furyl)ethyl]-8a-(hydroxymethyl)-5,6-dimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid

2-Methyl-2-propanyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate

Tert-butyl 3-iodo-5-nitro-1H-indazole-1-carboxylate

おすすめサプライヤー