Bacterial outer membrane vesicle-modified metal–organic frameworks for sonodynamic therapy–immunotherapy of breast cancer

文献情報

出版日 2023-11-23

DOI 10.1039/D3NJ03511E

インパクトファクター 3.591

著者

Ziwen Zhang, Jiawei Tu, Xiufeng Kuang, Mengya Shi, Yumeng Zhang, He Li, Jiesheng Huang, Li Wang, Huafang Yuan

原文を見る

要旨

Triple negative breast cancer seriously threatens the life health of women. Here, we develop a metal–organic framework based a nanoplatform for sonodynamic therapy–immunotherapy of breast cancer, loaded with the sonosensitizer chlorin e6 and modified bacterial outer membrane vesicles (OMVs). Sonodynamic therapy not only produced reactive oxygen species to kill tumor cells directly, but also promoted anti-tumor immunity. More importantly, OMV modification improved tumor targeting and immune activation of the nanoplatform, and further increased dendritic cell maturation and T cell infiltration in the tumor microenvironment. This novel therapeutic strategy led to a notable inhibitory effect on the development of breast cancer in mice.

掲載誌

New Journal of Chemistry

CiteScore: 5.3

自己引用率: 3.7%

年間論文数: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

Bacterial outer membrane vesicle-modified metal–organic frameworks for sonodynamic therapy–immunotherapy of breast cancer

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