Manufacturing of urea co-crystals by spiral gas–solid two-phase flow (S-GSF) based on spiral jet mills: a continuous, solvent-free, and scalable mechanochemical method
文献情報
Yong Song, Zhiyuan Jin, Jiawei Zhang, Bo Jin, Rufang Peng
In this work, we report a spiral gas–solid two-phase flow (S-GSF) method based on spiral jet mills for the continuous mechanochemical preparation of urea co-crystals for the first time. Urea–adipic acid (UAA), urea–catechol (URCAT), urea–salicylic acid (USA) and urea–gypsum (URCASU) co-crystals were prepared to demonstrate the feasibility of this approach. The prepared products were characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. The results showed that powdered products of the urea co-crystals can be obtained continuously by using this method without the addition of any solvent in the preparation process. Moreover, the UAA co-crystal prepared by S-GSF is in single polycrystalline form I, while form II, which appears in milling and ball milling, is not observed. The transcrystallization behavior among different polymorphs of the UAA co-crystal was studied and their thermodynamic stability was investigated by theoretical calculations. The results indicated that form I is a thermodynamically stable polymorph, and S-GSF is selective for the formation of form I. This phenomenon can be attributed to the fact that S-GSF provides strong mechanical action, as well as a low-temperature reaction environment, which distinguishes it from existing mechanochemical methods.
おすすめジャーナル

Nature Reviews Drug Discovery

Green Chemistry

Advanced Engineering Materials

Environmental Toxicology and Pharmacology

Foundations of Chemistry

Photochemical & Photobiological Sciences

Angewandte Chemie International Edition

Journal of Enzyme inhibition and Medicinal Chemistry

Molecular Diversity

Journal of Medical Biochemistry
関連文献
The planar electric double layer capacitance for the solvent primitive model electrolyte
Stanisław Lamperski, Monika Płuciennik, Christopher W. Outhwaite
DOI: 10.1039/C4CP03513E
Schiff base ligands and their transition metal complexes in the mixtures of ionic liquid + organic solvent: a thermodynamic study
Hemayat Shekaari, Amir Kazempour, Maryam Khoshalhan
DOI: 10.1039/C4CP04432K
Intra-residue interactions in proteins: interplay between serine or cysteine side chains and backbone conformations, revealed by laser spectroscopy of isolated model peptides
Himansu S. Biswal
DOI: 10.1039/C4CP04449E
Revisiting the conundrum of trehalose stabilization
Nidhi Katyal, Shashank Deep
DOI: 10.1039/C4CP02914C
Whirl-enhanced continuous wave laser trapping of particles‡
S. Bartkiewicz, A. Miniewicz
DOI: 10.1039/C4CP04008B
Complex behaviour of vacancy point-defects in SrRuO3 thin films
Henning Schraknepper, Christoph Bäumer, Regina Dittmann, Roger A. De Souza
DOI: 10.1039/C4CP03632H
Modulation of physical properties of supramolecular hydrogels based on a hydrophobic core
Masashi Ohno, Shun Fujita, Kowichiro Saruhashi, Nobuhide Miyachi, Katsuaki Miyaji
DOI: 10.1039/C4CP04395B
The role of Schottky barrier in the resistive switching of SrTiO3: direct experimental evidence
Xue-Bing Yin, Zheng-Hua Tan, Xin Guo
DOI: 10.1039/C4CP04151H
Compressibility, thermal expansion coefficient and heat capacity of CH4 and CO2 hydrate mixtures using molecular dynamics simulations
F. L. Ning, K. Glavatskiy, Z. Ji, T. J. H. Vlugt
DOI: 10.1039/C4CP04212C
こちらもおすすめ
1-{3-[5-(エチルカルボンイル)-2,4-ジメチル-1H-ピロロール-3-基]プロパニル}ピペリジン-4-カルボン酸について、適用される法規ガイドラインは何ですか?
この化合物はCAS番号1142209-81-1であり、GHS分類では corrosive (腐食性物質) と classified (分類物質) として指定され...
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸とは何ですか?
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸は、CAS番号656-46-2の化合物で、化学式はC8H4F2O4です。この化合物は白色の結晶性粉...
8-氯-4-色原酮の代替品はありますか?
8-氯-4-色原酮(CAS番号: 49701-11-3)の代替品には、他の色原酮類似物や、構造が似ている化合物があります。例えば、8-メチル-4-色原酮や、他の...
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートとは何ですか?
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートは、CAS番号1233243-56-5を有する化合物です。これは有...
4-叔丁基-6-氯-嘧啶に適用される法規ガイドラインは何ですか?
4-叔丁基-6-氯-嘧啶はCAS番号3435-24-3で、GHS分類では毒性物質とみなし、GHSの危険性分類が適用されます。REACH規則では登録が必要で、Eu...
維库溴铵杂质Bはどのように合成されますか?
維库溴铵杂质Bは、アンドロステンデンから始まり、一連の合成反応、包括的な選択性と高い収率で合成されます。具体的には、ブロミド化、酸化、ジマーゼ反応、アミド化など...
2-(4-氟苄基)-吡咯烷の物理化学的性質は何ですか?
CAS番号350017-04-8の2-(4-氟苄基)-吡咯烷は、結晶性の白色粉末です。分子量は199.17 g/molで、水に溶けにくいです。化学反応では比較的...
3-喹啉甲醛(2-チロール-8-エチル)は安全ですか?
3-喹啉甲醛(2-チロール-8-エチル)は一定の毒性を持つため、取扱には注意が必要です。使用する際は適切な防護具を着用し、密閉容器で保管・搬送し、直接的な接触を...
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートはどのように保存すればよいですか?
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートは、室温(25℃)以下で保存し、直射日光を避け、乾燥した環境で保管することが推奨されます。ま...
掲載誌
CrystEngComm

CrystEngComm is the forum for the design and understanding of crystalline materials. We welcome studies on the investigation of molecular behaviour within crystals, control of nucleation and crystal growth, engineering of crystal structures, and construction of crystalline materials with tuneable properties and functions. We publish hypothesis-driven research into… how crystal design affects thermodynamics, phase transitional behaviours, polymorphism, morphology control, solid state reactivity (crystal-crystal solution-crystal, and gas-crystal reactions), optoelectronics, ferroelectric materials, non-linear optics, molecular and bulk magnetism, conductivity and quantum computing, catalysis, absorption and desorption, and mechanical properties. Using Techniques and methods including… Single crystal and powder X-ray, electron, and neutron diffraction, solid-state spectroscopy, spectrometry, and microscopy, modelling and data mining, and empirical, semi-empirical and ab-initio theoretical evaluations. On crystalline and solid-state materials. We particularly welcome work on MOFs, coordination polymers, nanocrystals, host-guest and multi-component molecular materials. We also accept work on peptides and liquid crystals. All papers should involve the use or development of a design or optimisation strategy. Routine structural reports or crystal morphology descriptions, even when combined with an analysis of properties or potential applications, are generally considered to be outside the scope of the journal and are unlikely to be accepted.
![[2',6'-bis(propan-2-yloxy)-[1,1'-biphenyl]-3-yl]dicyclohexylphosphane structure [2',6'-bis(propan-2-yloxy)-[1,1'-biphenyl]-3-yl]dicyclohexylphosphane structure](https://static.chemtradehub.com/structs/787/787618-22-8-dda2.webp)


![Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure Bis[(1,2,3,4,5-eta)-1-(diphenylphosphino)cyclopentadienyl]iron structure](https://static.chemtradehub.com/structs/121/12150-46-8-ecd2.webp)
