Iodine-dependent oxidative regioselective aminochalcogenation of indolines

文献情報

出版日 2024-01-03

DOI 10.1039/D3CC05999E

インパクトファクター 6.222

著者

Xiaoxiang Zhang, Chenrui Liu, Wanxing Wei, Zhuan Zhang, Taoyuan Liang

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要旨

A directing-group-free strategy for oxidative regioselective aminochalcogenation of indolines with amines and dichalconides is presented. This strategy combines tandem coupling sequences and oxidative dehydrogenation methods in a multi-component reaction, enabling the fast construction of a series of C2,3- or C2,5-aminochalcogenated indole derivatives. Moreover, the application of this synthetic approach is demonstrated through the late-stage modification of pharmaceuticals and the derivatization of the products, highlighting its potential and significance.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

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