A bioluminescent probe for NQO1 overexpressing cancer cell imaging in vitro and in vivo

文献情報

出版日 2022-10-28

DOI 10.1039/D2AN01435A

インパクトファクター 4.616

著者

Yuhong Luo, Wentao Wang, Yi Zeng, Shuangqing Wang, Xudong Guo, Rui Hu, Guoqiang Yang

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要旨

NAD(P)H quinone oxidoreductase1 (NQO1) is a flavoenzyme that regulates the redox potential level in cells. Overexpression of NQO1 has been proven to be relevant to some malignant tumors. Herein a bioluminescent probe NQO1-Luc equipped with an NQO1-targeting group, trimethyl-locked quinone propionic acid (QPA), was constructed. The reduction of NQO1-Luc could be triggered by NQO1, resulting in the release of free D-luciferin, and concomitantly a bright bioluminescence emission. NQO1-Luc exhibits high selectivity and sensitivity toward NQO1 activity and the capability of distinguishing NQO1-overexpressing cells in vitro and in vivo, which offers a promising tool for investigations of NQO1 related biological processes including tumors in living organisms.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A bioluminescent probe for NQO1 overexpressing cancer cell imaging in vitro and in vivo

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