Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex

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出版日 2022-09-20

DOI 10.1039/D2AN01257J

インパクトファクター 4.616

著者

Waralee Srinarawat, Ruedee Hemstapat, Tulyapruek Tawonsawatruk, Nisa Patikarnmonthon, Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep

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要旨

Calcium pyrophosphate deposition disease, previously known as pseudogout, is a type of chronic and painful joint arthropathy. Accurate identification of calcium pyrophosphate dihydrate (CPPD) single crystals is crucial for determining the best course of treatment. In this study, a two-step method involving alizarin red S (ARS) and a xanthene dipicolylamine ZnII (XDZ) complex was employed for the identification of CPPD single crystals in both triclinic and monoclinic forms using a fluorescence microscope and a microplate reader. The accurate identification method proposed in this study has the potential to advance the diagnosis and treatment of patients suffering from painful gouty arthritis.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

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Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex

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