Developing flow photo-thiol–ene functionalizations of cinchona alkaloids with an autonomous self-optimizing flow reactor

文献情報

出版日 2022-02-28

DOI 10.1039/D1RE00509J

インパクトファクター 4.239

著者

Abollé Abollé, Elvina Barré, Vincent Coeffard, François-Xavier Felpin

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要旨

Continuous flow photo-thiol–ene reactions on cinchona alkaloids with a variety of organic thiols have been developed to deliver a series of unprecedented architectures. A self-optimizing flow photochemical reactor was deployed to identify optimal experimental conditions. The flow thiol–ene reaction proceeds under mild conditions upon irradiation of the reaction mixture at 365 nm for 30 minutes in a custom built flow photochemical reactor. The short path length offered by the tubular photochemical reactor maximizes the absorption of photons emitted by the light source and increases both rates and reaction yields compared to a traditional batch reactor.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.