2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)–C(sp3) bonds

文献情報

出版日 2021-11-23

DOI 10.1039/D1QO01446C

インパクトファクター 5.281

著者

Chuan-Ming Hong, Fei-Fei Zou, Xin Zhuang, Zhen Luo, Zheng-Qiang Liu, Li-Qing Ren, Qing-Hua Li, Tang-Lin Liu

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要旨

A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones, using (pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy, has been disclosed. This approach provides an efficient, available and environmentally benign access, leading to alkylation products with broad functional group tolerance and excellent yields. Meanwhile, the selective cleavage of unactivated C(sp3)–C(sp3) bonds of common secondary alcohols was achieved with high atom economy.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)–C(sp3) bonds

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