Copper-catalyzed regio- and stereoselective fluorocarboalkynylation of alkynes

文献情報

出版日 2021-10-06

DOI 10.1039/D1QO01201K

インパクトファクター 5.281

著者

Binlin Zhao, Yukun Zheng, Tianxiang Zhu, Mengning Wang, Minyan Wang, Mengtao Ma

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要旨

It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1,3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-catalyzed regio- and stereoselective fluorocarboalkynylation of alkynes

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