Hydroxyl group-directed, tartaric acid-catalyzed synthesis of meta-functionalized aryl ethers and phenols through domino conjugate addition/aromatization of para-quinols

文献情報

出版日 2021-10-02

DOI 10.1039/D1QO01078F

インパクトファクター 5.281

著者

Guo-Shu Chen, Jia-Hui Li, Shu-Jie Chen, Wen-Xia Lin, Hai Ren, Dong-Sheng Deng, Yun-Lin Liu

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要旨

A tartaric acid-catalyzed three-component reaction of para-quinols, organoboronic acids, and alcohols is reported, leading to meta-alkenylated aryl alkyl ether in a single step. Moreover, meta-functionalized phenols could also be obtained in the absence of alcohols. Initial mechanistic studies indicated that the free hydroxy group of p-quinol plays a vital role in initiating the conjugate addition.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Hydroxyl group-directed, tartaric acid-catalyzed synthesis of meta-functionalized aryl ethers and phenols through domino conjugate addition/aromatization of para-quinols

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