A novel p-dimethylaminophenylether-based fluorescent probe for the detection of native ONOO− in cells and zebrafish

文献情報

出版日 2021-07-15

DOI 10.1039/D1AN00608H

インパクトファクター 4.616

著者

Wenlong Sheng, Kun Wang, Na Gao, Lizhen Wang, Rongchun Wang, Xuanming Zhang, Xiqiang Chen, Yun Zhang, Baocun Zhu, Kechun Liu

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要旨

Peroxynitrite (ONOO−) is a highly reactive substance, and plays an essential part in maintaining cellular homeostasis. It is crucial to monitor the ONOO− level in cells in normal and abnormal states. We introduced a p-dimethylaminophenylether-based fluorescent probe PDPE-PN, which could be synthesized readily. The new probe had prominent sensitivity and specificity, and a fast response towards ONOO−. The spectral performance of probe PDPE-PN was outstanding and the limit of detection was 69 nM. Probe PDPE-PN with low toxicity was applied to detect endogenous/exogenous ONOO− in RAW 264.7 macrophages and zebrafish. Importantly, successful application of the new receptor opens up new ideas for the design of ONOO− probes.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A novel p-dimethylaminophenylether-based fluorescent probe for the detection of native ONOO− in cells and zebrafish

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