Carbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihyropyrimidin-4-ones

文献情報

出版日 2020-12-11

DOI 10.1039/D0QO01380C

インパクトファクター 5.281

著者

Rakesh Maiti, Jia-Lei Yan, Bivas Mondal, Xing Yang, Huifang Chai, Lin Hao, Zhichao Jin

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要旨

A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions is reported. The key steps of our reactions involve the formation of two carbon–nitrogen bonds in a highly regio-selective manner. A variety of sulphur-containing 5,6-dihydropyrimidin-4-ones are obtained with high optical purity.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Carbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihyropyrimidin-4-ones

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