Phosphatediesters cleavage mediated by Ce(iv) complexes self-assembled on gold nanoparticles

文献情報

出版日 2010-03-29

DOI 10.1039/B926916A

インパクトファクター 3.876

著者

Renato Bonomi, Paolo Scrimin, Fabrizio Mancin

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要旨

Monolayer protected gold nanoparticles (MPGN) coated with metal chelating groups were prepared. In the presence of Ce(IV), the MPGN proved to be highly active in promoting the hydrolytic cleavage of the DNA model bis-p-nitrophenyl phosphate (BNP). A 2.5 million-fold rate acceleration of the BNP hydrolysis was measured at a concentration of Ce(IV) as low as 120 μM (pH 7, 25 °C). This corresponds to a reduction of the substrate half-life time from 2000 years to few hours. The MPGN-Ce(IV) system is 1 to 2 orders of magnitude more reactive than any mono- and binuclear Ce(IV) complex so far reported. The source of such reactivity is the cooperation between the metal ions self-organized on the surface of the nanoparticles.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Phosphatediesters cleavage mediated by Ce(iv) complexes self-assembled on gold nanoparticles

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