HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues

文献情報

出版日 2020-03-10

DOI 10.1039/D0QO00081G

インパクトファクター 5.281

著者

Xiaoyu Bai, Bowei Yang, Hansen Chen, Jiangang Shen, Dan Yang

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要旨

In order to understand the production and functions of HOCl in biological systems, a sensitive and selective detection method is urgently needed, especially for HOCl visualization in living cells and tissues. Herein we report a highly sensitive and selective rhodol-based fluorescent probe HKOCl-4 for HOCl detection. HKOCl-4r and HKOCl-4m, which were designed for better cellular uptake and mitochondria-targeting, respectively, have been successfully applied in detecting endogenous HOCl in macrophages. Furthermore, HOCl production in ischemic rat brain tissues has been visualized with HKOCl-4r in a middle cerebral artery occlusion (MCAO) model. These probes would serve as powerful imaging tools for delving into the roles of HOCl in health and disease.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

HKOCl-4: a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues

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