Stereoselective defluorinative carboxylation of gem-difluoroalkenes with carbon dioxide

文献情報

出版日 2019-09-16

DOI 10.1039/C9QO00923J

インパクトファクター 5.281

著者

Shi-Liang Xie, Xiao-Yuan Cui, Xiao-Tong Gao, Hai-Hong Wu

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要旨

We report the copper-catalyzed defluorinative carboxylation of gem-difluoroalkenes with CO2. Using cheap and easily available CuI as the catalyst and bis(pinacolatodiboron) as the stoichiometric reductant, the reaction efficiently converts the alkenyl C–F bond to a carboxyl group with complete retention of stereochemistry, thus providing fluoroalkenyl carboxylic acids in good to excellent yields.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Stereoselective defluorinative carboxylation of gem-difluoroalkenes with carbon dioxide

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