Enynone-enabled migratory insertion and Schmittel cyclization cascade for the synthesis of furan-fused fluorenes

文献情報

出版日 2019-02-21

DOI 10.1039/C9QO00045C

インパクトファクター 5.281

著者

He Zhang, Tongxiang Cao, Hejiang Luo, Lianfen Chen, Shifa Zhu

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要旨

A new method for the synthesis of furan-/benzo-fused fluorenes through copper(I)-catalyzed coupling of conjugated enynones or α-diazocarbonyl compounds with dialkynylbenzenes has been developed. This process includes 5-exo-dig cyclization, carbene migratory insertion, Schmittel cyclization and 1,5-H transfer. The obvious advantages of wide substrate scopes, mild reaction conditions, and high atom efficiency make this system highly appealing for the construction of six-substituted benzofuran-embedded fluorenes in a one-pot manner.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Enynone-enabled migratory insertion and Schmittel cyclization cascade for the synthesis of furan-fused fluorenes

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