Assembly of miscible supramolecular network blends using DDA·AAD hydrogen-bonding interactions of pendent side-chains

文献情報

出版日 2020-05-12

DOI 10.1039/C9PY01913H

インパクトファクター 5.582

著者

Heather M. Coubrough, Matthew Reynolds, James A. Goodchild, Simon D. A. Connell, Johan Mattsson

原文を見る

要旨

The formation of polymer blends can result in materials with superior properties through combination of homo- or co-polymers with divergent functionalities. However, the contrasting physical properties of different polymers often result in phase separation. Herein we induce miscible blend formation of immiscible poly(methyl methacrylate) and polystyrene polymers through triple donor–donor–acceptor and acceptor–acceptor–donor (DDA·AAD) hydrogen bonding between complementary heterodimers on pendent side-chains. RAFT polymerization is used to synthesize a series of poly (methylmethacrylate) and polystyrene co-polymers bearing complementary side-chain hydrogen bonding motifs. Mixing of these polymers promoted miscible blend formation as demonstrated by atomic force microscopy and differential scanning calorimetry. The effectiveness of blend formation was shown to depend upon the extent of incorporation of hydrogen-bonding motif bearing co-monomer; lower degrees of incorporation lead to ineffective blending, whereas higher degree of incorporation, suppress phase separation and promote miscibility.

関連文献

Synthesis and antitumour evaluation of indole-2-carboxamides against paediatric brain cancer cells

Shahinda S. R. Alsayed, Amreena Suri, Anders W. Bailey, Samuel Lane, Chiang-Ching Huang, Li-Fang Yu, Michael Kassiou, Hendra Gunosewoyo

2021-08-23 Research Article

DOI: 10.1039/D1MD00065A

Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach

Lewis D. Turner, Lucy Lin, Sabine Pellett, Takashi Sugane, Eric A. Johnson, Kim D. Janda

2021-05-19 Research Article

DOI: 10.1039/D1MD00089F

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

Samir Yahiaoui, Katrin Voos, Jörg Haupenthal, Thomas A. Wichelhaus, Denia Frank, Lilia Weizel, Marco Rotter, Steffen Brunst, Jan S. Kramer, Ewgenij Proschak, Christian Ducho

2021-07-29 Research Article

DOI: 10.1039/D1MD00187F

The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health

Maximillian Taro William Lee, William Mahy, Mark David Rackham

2021-06-04 Review Article

DOI: 10.1039/D1MD00113B

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

2021-03-24 Review Article

DOI: 10.1039/D1MD00022E

Target 2035 – update on the quest for a probe for every protein

Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Hartmut Beck, Shaunna Beedie, Ulrich A. K. Betz, Gustavo Arruda Bezerra, Paul E. Brennan, David Brown, Peter J. Brown, Alex N. Bullock, Adrian J. Carter, Apirat Chaikuad, Mathilde Chaineau, Alessio Ciulli, Ian Collins, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Stephen M. Fuchs, Matthew D. Hall, Ingo V. Hartung, Alexander Hillisch, Stephen H. Hitchcock, Evert Homan, Natarajan Kannan, James R. Kiefer, Stefan Knapp, Milka Kostic, Stefan Kubicek, Andrew R. Leach, Sven Lindemann, Hisanori Matsui, Jordan L. Meier, Maurice Michel, Maxwell R. Morgan, Anke Mueller-Fahrnow, Dafydd R. Owen, Benjamin G. Perry, Saul H. Rosenberg, Kumar Singh Saikatendu, Cora Scholten, Sujata Sharma, Anton Simeonov, Michael Sundström, Matthew H. Todd, Claudia Tredup, Timothy M. Willson, Georg E. Winter

2021-12-03 Opinion

DOI: 10.1039/D1MD00228G

Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

Ingrid Allart-Simon, Aurélie Moniot, Nicolo Bisi, Miguel Ponce-Vargas, Sandra Audonnet, Marie Laronze-Cochard, Janos Sapi, Eric Hénon, Frédéric Velard, Stéphane Gérard

2021-03-01 Research Article

DOI: 10.1039/D0MD00423E

Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains

Jeanette R. McConnell, H. Jane Dyson, Shelli R. McAlpine

2021-02-15 Research Article

DOI: 10.1039/D0MD00387E

Inside front cover

Cover

DOI: 10.1039/D0MD90044C

Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

Koichi Sasaki, Kyohei Muguruma, Rento Osawa, Akane Fukuda, Atsuhiko Taniguchi, Yoshio Hayashi

2021-01-21 Research Article

DOI: 10.1039/D0MD00337A

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Assembly of miscible supramolecular network blends using DDA·AAD hydrogen-bonding interactions of pendent side-chains

文献情報

おすすめジャーナル

関連文献

Synthesis and antitumour evaluation of indole-2-carboxamides against paediatric brain cancer cells

Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

Target 2035 – update on the quest for a probe for every protein

Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains

Inside front cover

Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

こちらもおすすめ

カルボニル基が付いた5-氰基-1-{[(2-メチル-2-プロpanyl)オキシ]カーボンイル}1H-吲哚-2-イリド-2-ボリン酸はどのように保存すればよいですか？

tert-ブチル2-クロロメチルピリジン-3-基炭酸エステルの市場動向や研究トレンドはどうですか？

聚二季戊四醇六丙烯酸酯はどの業界で使用されていますか？

1-氯-5-硝基异喹啉の市場動向や研究トレンドはどうですか？

2-チロール-5-メチルスルフェニル-3-trifルオルメチルベンゼンはどのように合成されますか？

p-トールイルマグネシウムブロミドの物理化学的性質は何ですか？

1-(5-甲基-2-硫化素基)プロパン-1-酮の市場動向や研究トレンドはどうですか？

十一碳烯酰甘氨酸を取り扱う際の実験室安全事項は何ですか？

1H,1H-全氟-3,6-二氧杂葵-1-醇を取り扱う際の実験室安全事項は何ですか？

3-(4-(フルオロメチルオキシ)フェニル)-1,2,4-オキサジアゾール-5-カルボハイドライドは安全ですか？

掲載誌

Polymer Chemistry

おすすめ化合物

2,3-Dibromoaniline

1-Bromo-4-(bromomethyl)-2,3-difluorobenzene

5,6-Difluoro-indan-2-one

6-Butyl-2-(2,4-difluorophenyl)-1,3,6,2-dioxazaborocane

2-Methyl-2-propanyl (2E)-5-chloro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]pentanoate

おすすめサプライヤー