Importance of the main chain of lysine for histone lysine methyltransferase catalysis

文献情報

出版日 2019-05-20

DOI 10.1039/C9OB01038F

インパクトファクター 3.876

著者

Abbas H. K. Al Temimi, Ruben S. Teeuwen, Vu Tran, Arthur J. Altunc, Danny C. Lenstra, Wansheng Ren, Ping Qian, Hong Guo

原文を見る

要旨

Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Importance of the main chain of lysine for histone lysine methyltransferase catalysis

文献情報

おすすめジャーナル

関連文献

Ultrafast dynamics of hemin aggregates

Coating agent-induced mechanical behavior of 3D self-assembled nanocrystals

Pattern transitions in a compressible floating elastic sheet

Molecular dynamics investigations of an indicator displacement assay mechanism in a liquid crystal sensor

Theoretical study on geometric, electronic and catalytic performances of Fe dopant pairs in graphene

Electronic structure and charge transport properties of atomic carbon wires

First-principles investigation of H2S adsorption and dissociation on titanium carbide surfaces

SO3 formation from the X-ray photolysis of SO2 astrophysical ice analogues: FTIR spectroscopy and thermodynamic investigations

General optimization procedure towards the design of a new family of minimal parameter spin-component-scaled double-hybrid density functional theory

Surface modification induced enhanced CO2 sorption in cucurbit[6]uril, an organic porous material

こちらもおすすめ

間溴苯甲酰腈の市場動向や研究トレンドはどうですか？

去磺基萝卜硫苷とは何ですか？

Methyl 2-amino-5-(trifluoromethyl)benzoateに適用される法規ガイドラインは何ですか？

3-ブロモ-1,3,4,5-四水化-2H-1-ベンザアゼピン-2-オンは安全ですか？

三氟甲基ピリジン-2-甲アミン塩酸塩は安全ですか？

1-エチル-4-(4-硝基フェニル)ピペリジンは安全ですか？

1,1-ジメトキシプロパン-2-オンは安全ですか？

コバルト(II) 3,3'-{[(1S,2S)-1,2-ジメチルフENCYCLICALE-1,2-エチエンジイル]ビス[ニトロリルメチルイリデン]}ビス[4-オキソ-2-ペンテン-2-olate]について「に適用される法規ガイドラインは何ですか？

「カーバミル酸, N-[8-[[2-[[2-(2,6-ジオキソ-3-ピペリジニル)-2,3-ジオキソ-1,3-ジヒドロ-1H-イソイソインドール-4-イルオキシ]アセチル]アミノ]オクチル]-1,1-ジメチレチルエステル」はどのように保存すればよいですか？

FMoc-D-4-Aph(tBu-CbM)-OHはどのように保存すればよいですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

(1R,3S,5R)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[3.1.0]hexane-3-carboxylic acid

(3,4-Difluoro-2-methoxyphenyl)boronic acid

(1S,4aR,5R,7S,7aS)-1-(beta-D-Glucopyranosyloxy)-5-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl alpha-D-galactopyranoside

1-Bromo-2-chloro-4-methoxybenzene

おすすめサプライヤー