Analysis of genome-wide in cell free DNA methylation: progress and prospect

文献情報

出版日 2019-08-22

DOI 10.1039/C9AN00935C

インパクトファクター 4.616

著者

Zhiyu Liu, Zexin Wang, Erteng Jia, Tinglan Ouyang, Min Pan, Jiafeng Lu, Qinyu Ge, Yunfei Bai

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要旨

DNA methylation is an important epigenetic marker that affects gene expression. Cell-free DNA methylation detection is a promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This review summarizes the existing literature and reviews on the detection methods based on next generation sequencing for DNA methylation. The review also discusses the feasibility of detecting cfDNA methylation and the latest progress.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Analysis of genome-wide in cell free DNA methylation: progress and prospect

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